20 pound dog ate 500 mg tylenol

20 pound dog ate 500 mg tylenol DEFAULT

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Have a headache?

Before you reach for Tylenol, make sure that you keep that bottle out of reach of your dog or cat! Tylenol contains the active ingredient acetaminophen (often called paracetamol in other countries), and is a popular over-the-counter (OTC) pain medication and anti-fever medication used by humans. While this drug is very safe for human use, it has a narrow margin of safety in dogs and cats.

Unfortunately, when dogs and cats ingest acetaminophen – either accidentally or because their pet owner inadvertently gave it to them, they can develop poisoning at low doses. The severity of acetaminophen poisoning depends on the species, as dogs and cats develop different clinical signs and problems with poisoning.

Because cats have altered liver metabolism (called glucuronidation), they metabolize acetaminophen poorly, making them much more susceptible to poisoning. The toxic dose of acetaminophen in cats is very low, seen at as little as 10 mg/kg. This means that as little as one Tylenol tablet could kill a cat.

In cats, acetaminophen poisoning affects the red blood cells (RBC). Cats develop methemoglobinemia (metHb), which means that their red blood cells can’t carry oxygen. As a result, clinical signs of poisoning in cats include:

  • Lethargy
  • Inappetance
  • Swelling of the face or paws
  • Difficulty breathing
  • An increased respiratory rate
  • Open mouth breathing
  • Vomiting
  • Anemia
  • Abnormal colored gums (from blue to brown instead of pink)
  • Liver failure (less common)
  • Death

In dogs, the toxic dose of acetaminophen poisoning is seen > 100 mg/kg. Dogs typically develop liver failure from acetaminophen, and with massive ingestions, methemoglobinemia (abnormal hemoglobin that can’t carry oxygen in the body) can also be seen. Clinical signs of acetaminophen poisoning in dogs include:

  • Dry eye (chronic squinting and abnormal green discharge of the eyes)
  • Inappetance
  • Lethargy
  • Vomiting
  • Black-tarry stool
  • Jaundiced gums
  • Increased liver enzymes
  • Walking drunk
  • Coma
  • Seizures

If your dog or cat gets into acetaminophen, it’s typically too late to induce vomiting, as the drug is rapidly absorbed from the stomach. Instead, treatment includes the following at your veterinary clinic:

  • Activated charcoal to bind up the poison from the stomach and intestines
  • Blood work to evaluate the RBC count, to look for the presence of methemoglobinemia, and to monitor the liver values
  • IV fluids
  • Liver protectants (such as SAMe, n-acetylcysteine)
  • Oxygen therapy, if needed
  • Blood transfusions, if needed
  • Monitoring of oxygen levels and blood pressure
  • Symptomatic supportive care

Thankfully, with acetaminophen poisoning, there’s an antidote called n-acetylcysteine (often abbreviated as NAC). Not all veterinarians carry this antidote, so if your pet got into a toxic amount of acetaminophen, referral to an emergency hospital or specialty clinic may be necessary.

The prognosis for acetaminophen poisoning is typically fair to good with supportive care and the use of the antidote. When in doubt, if you suspect your dog or cat got into acetaminophen, contact your veterinarian or emergency veterinarian right away and seek immediate veterinary attention (yes, even in the middle of the night). With any poisoning, the sooner you seek attention, the better the prognosis and the less costly or damaging to you and your pet.

If you have any questions or concerns, you should always visit or call your veterinarian – they are your best resource to ensure the health and well-being of your pets.

Sours: https://www.pethealthnetwork.com/dog-health/dog-toxins-poisons/tylenol-poisoning-dogs-and-cats

Acetaminophen (Tylenol) Toxicity in Dogs

Overview of Canine Acetaminophen (Tylenol) Toxicity

Acetaminophen is a medication commonly used to alleviate fever and pain. Common brands include Tylenol®, Percoset®, aspirin free Excedrin® and various sinus, cold and flu medications. Dogs most commonly receive toxic amounts of acetaminophen because owners medicate them without consulting a veterinarian. They also consume tablets that are dropped on the floor or left lying around.

Dogs are less sensitive to acetaminophen than cats. For example, a 50 pound dog would need to ingest over seven 500 mg tablets in order to suffer toxic effects. In the cat, one 250 mg acetaminophen tablet could be fatal.

In addition to severe liver failure, acetaminophen causes damage to red blood cells. These include:

  • Hemolysis, which is the destruction of red blood cells
  • Formation of Heinz bodies, which are defects in red cells that cause them to be removed from circulation sooner than normal
  • Formation of methemoglobin, a non-functional type of hemoglobin. Hemoglobin allows red blood cells to carry oxygen. When methemoglobin is formed, red blood cells cannot carry oxygen and the cat has difficulty breathing.

    What to Watch For

    The symptoms of acetaminophen toxicity in dogs develop in stages. Symptoms may occur more quickly or slowly depending on the amount ingested.

  • Stage 1 (0-12 hours). Symptoms include vomiting, dullness, difficulty breathing, development of brown-colored gums (instead of a normal pink color) and drooling.
  • Stage 2 (12-24 hours). Symptoms include swelling of the face, lips and limbs, uncoordinated movements, convulsions, coma and potential death.
  • Stage 3 (more than 24 hours). Symptoms are associated with liver failure and include a painful belly, jaundice (yellow tinge to gums, eyes and skin) and an inappropriate mental state.

Diagnosis of Acetaminophen Toxicity in Dogs

Prompt veterinary care is crucial to surviving the toxic effects of acetaminophen. If the dog is treated soon after ingestion there is a greater chance of survival, regardless of the amount ingested.

The diagnosis of acetaminophen toxicity is generally based on physical exam findings and a history of access or exposure to acetaminophen.

Blood levels of acetaminophen can be analyzed, but the results may not be accessible for hours to days. Determination of blood methemoglobin levels can help determine how long treatment will be necessary as well as determine prognosis. Not all veterinary clinics have the ability to measure the methemoglobin level.

Treatment of Acetaminophen (Tylenol) Toxicity in Dogs

Treatment is typically started as soon as the diagnosis is suspected, often in the absence of specific diagnostic test results. Blood work may be evaluated in order to assess the current function of the liver and the level of red blood cells and hemoglobin.

  • Hospitalization with continuous intravenous fluid therapy
  • Oxygen support
  • Activated charcoal to reduce the amount of acetaminophen absorbed by the stomach, if ingestion of the substance occurred within a few hours of admission to the hospital
  • Administration of acetylcysteine (Mucomyst®) to protect the liver from the toxic effects of acetaminophen. The medication cannot reverse liver damage that has already occurred but can help reduce further damage
  • Vitamin C to hasten elimination of the acetaminophen
  • Cimetidine (Tagamet®) to protect the liver from ongoing damage
  • In severe cases, blood transfusions and feeding tubes may be necessary

    Dogs intoxicated with acetaminophen are generally hospitalized for 2-4 days. Prognosis for survival is based on how quickly the dog receives treatment following ingestion of a toxic amount of acetaminophen. Severe liver damage is often seen and may result in death despite therapy.

Home Care and Prevention

There is no home care for acetaminophen toxicity. If you suspect that your dog has ingested a toxic amount of acetaminophen, (one pill or more), contact your family veterinarian or local veterinary emergency facility immediately.

After surviving acetaminophen toxicity, permanent liver damage may have occurred. Special diets and lifetime medications may be needed to counteract the liver damage.

The best preventative care is to give your dog medications only as directed by your veterinarian. Medications that may be safe for people can be fatal to dogs. Also, make sure that all medications are kept out of the reach of inquisitive dogs. Keeping medicine safely stored away can prevent many tragedies.


Sours: https://www.petplace.com/article/dogs/pet-health/acetaminophen-tylenol-toxicity-in-dogs/
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Tylenol (Acetaminophen) Poisoning in Dogs

Acetaminophen Toxicity in Dogs

Acetaminophen is one of the most commonly used pain relievers, and it can be found in a variety of over-the-counter medications. Toxic levels can be reached when a pet is unintentionally over medicated with acetaminophen, or when a pet has gotten hold of medication and ingested it. Pet owners often do not realize their animals may break into medicine cabinets or chew through medicine bottles. It is important to be able to recognize the symptoms of toxicity, so that you can properly treat your pet if they have accidentally ingested medication.

Symptoms and Types

The effects of acetaminophen poisoning are quite serious, often causing non-repairable liver damage. Dogs will typically experience acetaminophen toxicity at over 75 mg per kg body weight. The most common symptoms that you may notice in pets suffering from acetaminophen toxicity include:

  • Brownish-gray colored gums
  • Labored breathing
  • Swollen face, neck or limbs
  • Hypothermia (reduced body temperature)
  • Vomiting
  • Jaundice (yellowish color to skin, whites of eyes), due to liver damage
  • Coma


If you believe that your pet has ingested acetaminophen, it will typically be treated as an emergency situation. Seek the advice of a medical professional immediately, as treatment may be necessary. Your veterinarian will perform a chemical blood profile, a complete blood count, and a urinalysis to determine the level of toxicity, so that a potential treatment can be prescribed.


If your animal requires treatment, it will typically need to be given supplemental oxygen, intravenous fluids, and/or drugs given intravenously, including vitamin C, cimetidine, and N-acetylcysteine. The amino acid cystiene may also be used and is one of the most effective ingredients in this treatment regiment, necessary for repairing any potential liver damage. Cystiene can also work to reduce the overall level of toxicity in the body. Treatment in a timely fashion is essential to give your animal the best chance of recovery and survival.


While a veterinarian may recommend small doses of over-the-counter medication for animals, the weight of the animal, with regards to the dosage, is always taken into consideration. Dog owners should never self-diagnose and treat their pets with human medication, and should take precautions to keep household medications out of their dog's reach to avoid a potentially harmful or fatal reaction.

Sours: https://www.petmd.com/dog/conditions/digestive/c_dg_acetaminophen_toxicity

My dog is 31 pounds and accidentally consumed 650 mg of acetaminophen. Is she going to be okay???

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Pound dog 500 20 tylenol ate mg

Acetaminophen Toxicity in Cats and Dogs

High doses of acetaminophen can be toxic to cats and dogs
  • Acetaminophen can be toxic to dogs and cats, but cats are 7 to 10 times more susceptible to acetaminophen toxicity than dogs are.
  • Once swallowed, acetaminophen reaches the blood stream within 30 minutes; toxic effects are rapid and damage the liver and red blood cells.
  • Never give a medication intended for people to your pet unless instructed to do so by your veterinarian.

What Is Acetaminophen Toxicity?

Acetaminophen is the active ingredient in Tylenol and some other related medications that are used to treat pain and fever in people. Unfortunately, this drug can be extremely toxic (poisonous) to cats and dogs. Acetaminophen toxicity occurs when a cat or dog swallows enough of the drug to cause damaging effects in the body.

Acetaminophen is mostly metabolized (broken down and eliminated from the body) by the liver. Some of the substances that are created during this process can have harmful effects on cats and dogs. Cats are at much greater risk of toxicity than dogs because they lack certain proteins necessary for the liver to safely metabolize acetaminophen.

How Does Acetaminophen Toxicity Occur?

Many cases of acetaminophen toxicity in dogs and cats are accidental. A pet may find and chew on a bottle of pills or eat a pill that has fallen on the floor. Sadly, some cases occur because pet owners give medication intended for people to their pets without being instructed to do so by a veterinarian.

Acetaminophen is a drug meant for people. However, there are situations in which your veterinarian may prescribe a specific dosage of acetaminophen for your dog. Be sure to follow your veterinarian’s dosage directions very carefully and report any vomiting or other problems right away. Cats are 7 to 10 times more susceptible to acetaminophen toxicity than dogs are. Because cats are extremely sensitive to the drug’s toxic effects, acetaminophen is not given to cats.

What Are the Clinical Signs of Acetaminophen Toxicity?

Once swallowed, acetaminophen is rapidly absorbed from the stomach and intestines and can achieve significant levels in the blood within 30 minutes. The main toxic effects take two forms:

  • Liver damage: One of the substances produced by the breakdown of acetaminophen binds to liver cells, damaging them. Severe damage can lead to liver failure.
  • Damage to red blood cells: One of the substances produced by the breakdown of acetaminophen binds to red blood cells. Once bound, this substance changes hemoglobin (the protein in red blood cells that enables them to carry oxygen) into a molecule that is no longer able to carry oxygen. This means that the blood can no longer supply adequate amounts of oxygen to the body’s vital organs. The altered hemoglobin molecule is called methemoglobin; its lack of oxygen-carrying ability changes the color of blood from red to brown.

Cats and dogs can develop both forms of acetaminophen toxicity. However, cats are more likely to suffer hemoglobin damage while dogs are more likely to suffer liver damage. The main clinical signs associated with acetaminophen toxicity that result from liver injury and an inability of the blood to carry oxygen include:

  • Vomiting
  • Decreased appetite
  • Lethargy (tiredness)
  • Difficult or rapid breathing
  • Abdominal pain
  • Brown discoloration of the gums (a result of methemoglobin)
  • Brown urine
  • Blue gums (known as cyanosis, indicates inadequate oxygen supply)
  • Swelling of the face or paws
  • Shock, collapse, death

How Is Acetaminophen Toxicity Diagnosed?

Diagnosis of acetaminophen toxicity is commonly based on a history of recently chewing or swallowing pills. Your veterinarian may recommend diagnostic testing, such as a chemistry panel and complete blood cell count (CBC), to assess the extent of the damage.

What Is the Treatment and Outcome for Pets Suffering from Acetaminophen Toxicity?

Acetaminophen is absorbed and metabolized very quickly. If you realize right away that your pet has swallowed acetaminophen, vomiting can be induced to remove the drug from your pet’s stomach before the body can absorb it. Another option may be to anesthetize your pet in order to flush out the contents of the stomach. Your veterinarian may also administer a special preparation of liquid activated charcoal to slow absorption of toxic material from the stomach and intestines.

There is a specific antidote for acetaminophen toxicity. This medication, N-acetylcysteine, limits formation of the toxic substance that damages the liver and red blood cells. Additional treatments may include blood transfusions, intravenous fluid therapy, and other medications to help support and stabilize the patient.

Acetaminophen toxicity can be fatal. However, pets can survive if the condition is recognized, diagnosed, and treated quickly.

Most cases of acetaminophen toxicity are preventable. Never give medications meant for people to your pet unless instructed to do so by your veterinarian, and keep all medications in the home secured to help prevent accidental swallowing.

This article has been reviewed by a Veterinarian.

Sours: http://www.vetstreet.com/care/acetaminophen-toxicity-in-cats-and-dogs
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